| 9/4/2021 | Maryville (4-6) | 14 | at | Berry | 20 | USASC | ||
| 9/11/2021 | Berry | 34 | at | LaGrange (2-8) | 21 | at USASC | ||
| 9/18/2021 | Berry | 7 | at | Wisconsin-Whitewater (13-1) | 39 | at WIAC | ||
| 10/2/2021 | Trinity TX (9-1,7-0) | 27 | at | Berry | 6 | |||
| 10/9/2021 | Berry | 49 | at | Millsaps (2-8,2-5) | 21 | |||
| 10/16/2021 | Sewanee (0-10,0-8) | 0 | at | Berry | 59 | |||
| 10/23/2021 | Berry | 42 | at | Hendrix (3-7,3-5) | 21 | |||
| 10/30/2021 | Birmingham-Southern (10-2,6-1) | 21 | at | Berry | 3 | |||
| 11/6/2021 | Berry | 45 | at | Rhodes (3-7,2-5) | 14 | |||
| 11/13/2021 | Centre (8-2,5-2) | 49 | at | Berry | 27 |
| vs Berry | vs Other Opponents | Berry compared to OOs | |
| Record: | 4-6 | 50-46 | |
| Points Scored: | 22.70 | 30.44 | 7.74 |
| Points Allowed: | 29.20 | 27.31 | 1.89 |
| Margin: | -6.50 | 3.13 | 9.63 |
| Total Points: | 51.90 | 57.75 | -5.85 |