| 9/2/2021 | Millsaps | 28 | at | Belhaven (7-3) | 56 | at ASWC | ||
| 9/18/2021 | Millsaps | 21 | at | Southwestern Assemblies of God (9-3) | 38 | at Soon | ||
| 9/25/2021 | Olivet (7-3) | 44 | at | Millsaps | 27 | MIAA | ||
| 10/2/2021 | Millsaps | 42 | at | Rhodes (3-7,2-5) | 21 | |||
| 10/9/2021 | Berry (6-4,4-3) | 49 | at | Millsaps | 21 | |||
| 10/16/2021 | Millsaps | 0 | at | Trinity TX (9-1,7-0) | 46 | |||
| 10/23/2021 | Centre (8-2,5-2) | 66 | at | Millsaps | 34 | |||
| 10/30/2021 | Sewanee (0-10,0-8) | 32 | at | Millsaps | 42 | |||
| 11/6/2021 | Millsaps | 7 | vs | Hendrix (3-7,3-5) | 34 | Little Rock AR | ||
| 11/13/2021 | Birmingham-Southern (10-2,6-1) | 49 | at | Millsaps | 7 |
| vs Millsaps | vs Other Opponents | Millsaps compared to OOs | |
| Record: | 8-2 | 54-40 | |
| Points Scored: | 43.50 | 31.26 | -12.24 |
| Points Allowed: | 22.90 | 24.88 | -1.98 |
| Margin: | 20.60 | 6.38 | -14.22 |
| Total Points: | 66.40 | 56.14 | 10.26 |