| 9/4/2021 | Hendrix | at | Austin (1-8) | Canceled COVID | ||||
| 9/11/2021 | Wisconsin-River Falls (9-2) | 49 | at | Hendrix | 33 | WIAC | ||
| 9/18/2021 | Hendrix | 21 | vs | Howard Payne (7-3) | 55 | Prosper TX | vs ASWC | |
| 9/25/2021 | Sewanee (0-10,0-8) | 27 | at | Hendrix | 49 | |||
| 10/2/2021 | Hendrix | 21 | at | Centre (8-2,5-2) | 42 | |||
| 10/9/2021 | Birmingham-Southern (10-2,6-1) | 43 | at | Hendrix | 6 | |||
| 10/16/2021 | Hendrix | 13 | at | Rhodes (3-7,2-5) | 16 | 2OT | ||
| 10/23/2021 | Berry (6-4,4-3) | 42 | at | Hendrix | 21 | |||
| 10/30/2021 | Hendrix | 13 | at | Trinity TX (9-1,7-0) | 62 | |||
| 11/6/2021 | Millsaps (2-8,2-5) | 7 | vs | Hendrix | 34 | Little Rock AR | ||
| 11/13/2021 | Hendrix | 56 | at | Sewanee (0-10,0-8) | 10 |
| vs Hendrix | vs Other Opponents | Hendrix compared to OOs | |
| Record: | 7-3 | 48-52 | |
| Points Scored: | 35.30 | 28.98 | -6.32 |
| Points Allowed: | 26.70 | 31.63 | -4.93 |
| Margin: | 8.60 | -2.65 | -11.25 |
| Total Points: | 62.00 | 60.61 | 1.39 |