| 9/4/2021 | McMurry (2-7) | at | Trinity TX | Canceled COVID | ASWC | |||
| 9/11/2021 | Macalester (3-7) | 0 | at | Trinity TX | 64 | MIA | ||
| 9/18/2021 | Trinity TX | 51 | at | Texas Lutheran (3-7) | 14 | at ASWC | ||
| 10/2/2021 | Trinity TX | 27 | at | Berry (6-4,4-3) | 6 | |||
| 10/9/2021 | Centre (8-2,5-2) | 7 | at | Trinity TX | 27 | |||
| 10/16/2021 | Millsaps (2-8,2-5) | 0 | at | Trinity TX | 46 | |||
| 10/23/2021 | Trinity TX | 66 | at | Sewanee (0-10,0-8) | 7 | |||
| 10/30/2021 | Hendrix (3-7,3-5) | 13 | at | Trinity TX | 62 | |||
| 11/6/2021 | Trinity TX | 28 | at | Birmingham-Southern (10-2,6-1) | 27 | |||
| 11/13/2021 | Rhodes (3-7,2-5) | 21 | at | Trinity TX | 55 | |||
| 11/20/2021 | Trinity TX | 3 | at | Mary Hardin-Baylor (15-0) | 13 | at ASWC |
| vs Trinity TX | vs Other Opponents | Trinity TX compared to OOs | |
| Record: | 1-9 | 54-52 | |
| Points Scored: | 10.80 | 30.47 | 19.67 |
| Points Allowed: | 42.90 | 27.68 | 15.22 |
| Margin: | -32.10 | 2.79 | 34.89 |
| Total Points: | 53.70 | 58.15 | -4.45 |