| 9/4/2021 | Waynesburg (2-8) | 6 | at | Muskingum | 49 | TPAC | ||
| 9/11/2021 | Ohio Northern (4-6,3-6) | 31 | at | Muskingum | 33 | |||
| 9/18/2021 | Muskingum | 0 | at | Marietta (4-6,4-5) | 18 | |||
| 9/25/2021 | Wilmington (2-7,2-6) | 14 | at | Muskingum | 62 | |||
| 10/2/2021 | Muskingum | 7 | at | John Carroll (7-3,7-2) | 29 | |||
| 10/16/2021 | Baldwin-Wallace (8-2,7-2) | 49 | at | Muskingum | 10 | |||
| 10/23/2021 | Muskingum | 31 | at | Otterbein (1-9,1-8) | 14 | |||
| 10/30/2021 | Heidelberg (7-2,6-2) | 49 | at | Muskingum | 14 | |||
| 11/6/2021 | Muskingum | 7 | at | Mount Union (13-1,9-0) | 73 | |||
| 11/13/2021 | Muskingum | 46 | at | Capital (2-8,1-8) | 27 |
| vs Muskingum | vs Other Opponents | Muskingum compared to OOs | |
| Record: | 5-5 | 45-47 | |
| Points Scored: | 31.00 | 27.47 | -3.53 |
| Points Allowed: | 25.90 | 28.00 | -2.10 |
| Margin: | 5.10 | -0.53 | -5.63 |
| Total Points: | 56.90 | 55.47 | 1.43 |