| 9/11/2021 | Aurora (8-3) | 7 | at | North Central | 64 | NAC | ||
| 9/18/2021 | North Central | 20 | at | Wheaton (10-2,8-1) | 7 | |||
| 9/25/2021 | Augustana IL (5-5,4-5) | 6 | at | North Central | 58 | |||
| 10/2/2021 | North Central | 62 | at | Carroll WI (6-4,5-4) | 7 | |||
| 10/9/2021 | North Central | 64 | at | Carthage (3-7,3-6) | 13 | |||
| 10/16/2021 | Elmhurst (1-9,1-8) | 7 | at | North Central | 77 | |||
| 10/23/2021 | Illinois Wesleyan (3-7,3-6) | 7 | at | North Central | 55 | |||
| 10/30/2021 | North Central | 54 | at | Millikin (3-7,3-6) | 27 | |||
| 11/6/2021 | North Central | 59 | at | Washington U (7-4,7-2) | 20 | |||
| 11/13/2021 | North Park (2-8,2-7) | 6 | at | North Central | 84 | |||
| 11/20/2021 | Carnegie Mellon (8-2) | at | North Central | Cancelled | TPAC | |||
| 11/27/2021 | Wisconsin-La Crosse (9-3) | 20 | at | North Central | 34 | WIAC | ||
| 12/4/2021 | Rensselaer (11-2) | 6 | at | North Central | 55 | LL | ||
| 12/11/2021 | North Central | 26 | at | Mount Union (13-1) | 13 | D3 Semifinal | at OAC | |
| 12/17/2021 | Mary Hardin-Baylor (15-0) | 57 | vs | North Central | 24 | D3 Championship - Canton OH | ASWC |
| vs North Central | vs Other Opponents | North Central compared to OOs | |
| Record: | 1-13 | 103-51 | |
| Points Scored: | 14.50 | 33.08 | 18.58 |
| Points Allowed: | 52.57 | 22.25 | 30.32 |
| Margin: | -38.07 | 10.83 | 48.90 |
| Total Points: | 67.07 | 55.33 | 11.74 |