| 9/4/2021 | Heidelberg | 48 | at | Adrian (5-5) | 20 | at MIAA | ||
| 9/11/2021 | Wilmington (2-7,2-6) | at | Heidelberg | Cancelled | ||||
| 9/18/2021 | Capital (2-8,1-8) | 17 | at | Heidelberg | 48 | |||
| 9/25/2021 | Heidelberg | 10 | at | Baldwin-Wallace (8-2,7-2) | 20 | |||
| 10/9/2021 | Heidelberg | 44 | at | Marietta (4-6,4-5) | 21 | |||
| 10/16/2021 | Otterbein (1-9,1-8) | 19 | at | Heidelberg | 52 | |||
| 10/23/2021 | Mount Union (13-1,9-0) | 49 | at | Heidelberg | 14 | |||
| 10/30/2021 | Heidelberg | 49 | at | Muskingum (5-5,4-5) | 14 | |||
| 11/6/2021 | John Carroll (7-3,7-2) | 21 | at | Heidelberg | 27 | OT | ||
| 11/13/2021 | Heidelberg | 33 | at | Ohio Northern (4-6,3-6) | 32 |
| vs Heidelberg | vs Other Opponents | Heidelberg compared to OOs | |
| Record: | 2-7 | 49-45 | |
| Points Scored: | 23.67 | 28.56 | 4.89 |
| Points Allowed: | 36.11 | 25.83 | 10.28 |
| Margin: | -12.44 | 2.73 | 15.17 |
| Total Points: | 59.78 | 54.39 | 5.39 |