| 9/4/2021 | Washington & Jefferson (8-3) | 21 | at | John Carroll | 14 | TPAC | ||
| 9/18/2021 | John Carroll | 41 | at | Otterbein (1-9,1-8) | 17 | |||
| 9/25/2021 | Mount Union (13-1,9-0) | 28 | at | John Carroll | 14 | |||
| 10/2/2021 | Muskingum (5-5,4-5) | 7 | at | John Carroll | 29 | |||
| 10/9/2021 | John Carroll | 38 | at | Capital (2-8,1-8) | 7 | |||
| 10/16/2021 | Ohio Northern (4-6,3-6) | 17 | at | John Carroll | 27 | |||
| 10/23/2021 | John Carroll | 19 | at | Marietta (4-6,4-5) | 10 | |||
| 10/30/2021 | Wilmington (2-7,2-6) | 7 | at | John Carroll | 50 | |||
| 11/6/2021 | John Carroll | 21 | at | Heidelberg (7-2,6-2) | 27 | OT | ||
| 11/13/2021 | John Carroll | 29 | at | Baldwin-Wallace (8-2,7-2) | 28 |
| vs John Carroll | vs Other Opponents | John Carroll compared to OOs | |
| Record: | 3-7 | 51-42 | |
| Points Scored: | 16.90 | 30.67 | 13.77 |
| Points Allowed: | 28.20 | 26.37 | 1.83 |
| Margin: | -11.30 | 4.30 | 15.60 |
| Total Points: | 45.10 | 57.04 | -11.94 |