| 9/4/2021 | Coe | 38 | at | Cornell IA (4-6) | 7 | at MidW | ||
| 9/11/2021 | Hope (8-2) | 21 | at | Coe | 28 | MIAA | ||
| 9/18/2021 | Simpson (1-9,1-7) | 22 | at | Coe | 42 | |||
| 9/25/2021 | Coe | 7 | at | Wartburg (7-3,6-2) | 28 | |||
| 10/9/2021 | Central IA (12-1,8-0) | 55 | at | Coe | 21 | |||
| 10/16/2021 | Coe | 27 | at | Loras (4-6,4-4) | 20 | |||
| 10/23/2021 | Luther (0-10,0-8) | 7 | at | Coe | 63 | |||
| 10/30/2021 | Coe | 34 | at | Dubuque (6-4,5-3) | 27 | |||
| 11/6/2021 | Buena Vista (5-5,4-4) | 28 | at | Coe | 31 | |||
| 11/13/2021 | Coe | 53 | at | Nebraska Wesleyan (4-6,2-6) | 21 |
| vs Coe | vs Other Opponents | Coe compared to OOs | |
| Record: | 2-8 | 49-44 | |
| Points Scored: | 23.60 | 30.56 | 6.96 |
| Points Allowed: | 34.40 | 29.41 | 4.99 |
| Margin: | -10.80 | 1.15 | 11.95 |
| Total Points: | 58.00 | 59.97 | -1.97 |