| 9/4/2021 | Eureka (2-8) | 20 | at | Nebraska Wesleyan | 69 | NAC | ||
| 9/11/2021 | Nebraska Wesleyan | 20 | at | Augsburg (4-6) | 19 | at MIA | ||
| 9/18/2021 | Nebraska Wesleyan | 7 | at | Central IA (12-1,8-0) | 37 | |||
| 9/25/2021 | Loras (4-6,4-4) | 31 | at | Nebraska Wesleyan | 30 | |||
| 10/2/2021 | Nebraska Wesleyan | 28 | at | Luther (0-10,0-8) | 21 | |||
| 10/9/2021 | Dubuque (6-4,5-3) | 31 | at | Nebraska Wesleyan | 14 | |||
| 10/16/2021 | Nebraska Wesleyan | 7 | at | Buena Vista (5-5,4-4) | 50 | |||
| 10/30/2021 | Simpson (1-9,1-7) | 14 | at | Nebraska Wesleyan | 44 | |||
| 11/6/2021 | Nebraska Wesleyan | 14 | at | Wartburg (7-3,6-2) | 50 | |||
| 11/13/2021 | Coe (8-2,6-2) | 53 | at | Nebraska Wesleyan | 21 |
| vs Nebraska Wesleyan | vs Other Opponents | Nebraska Wesleyan compared to OOs | |
| Record: | 6-4 | 43-50 | |
| Points Scored: | 32.60 | 31.04 | -1.56 |
| Points Allowed: | 25.40 | 33.72 | -8.32 |
| Margin: | 7.20 | -2.68 | -9.88 |
| Total Points: | 58.00 | 64.76 | -6.76 |