| 9/4/2021 | Simpson | 6 | at | Mary Hardin-Baylor (15-0) | 84 | at ASWC | ||
| 9/11/2021 | Wisconsin-Stevens Point (2-8) | 34 | at | Simpson | 7 | WIAC | ||
| 9/18/2021 | Simpson | 22 | at | Coe (8-2,6-2) | 42 | |||
| 9/25/2021 | Central IA (12-1,8-0) | 84 | at | Simpson | 16 | |||
| 10/2/2021 | Simpson | 13 | at | Loras (4-6,4-4) | 21 | |||
| 10/9/2021 | Luther (0-10,0-8) | 34 | at | Simpson | 68 | |||
| 10/16/2021 | Simpson | 28 | at | Dubuque (6-4,5-3) | 41 | |||
| 10/23/2021 | Buena Vista (5-5,4-4) | 50 | at | Simpson | 19 | |||
| 10/30/2021 | Simpson | 14 | at | Nebraska Wesleyan (4-6,2-6) | 44 | |||
| 11/13/2021 | Wartburg (7-3,6-2) | 55 | at | Simpson | 23 |
| vs Simpson | vs Other Opponents | Simpson compared to OOs | |
| Record: | 9-1 | 54-44 | |
| Points Scored: | 48.90 | 31.45 | -17.45 |
| Points Allowed: | 21.60 | 27.62 | -6.02 |
| Margin: | 27.30 | 3.83 | -23.47 |
| Total Points: | 70.50 | 59.07 | 11.43 |