| 9/4/2021 | Coe (8-2) | 38 | at | Cornell IA | 7 | ARC | ||
| 9/11/2021 | Beloit (0-10,0-9) | 7 | at | Cornell IA | 38 | |||
| 9/18/2021 | Cornell IA | 13 | at | Ripon (6-3,5-3) | 31 | |||
| 10/2/2021 | Cornell IA | 0 | at | Lake Forest (10-1,9-0) | 17 | |||
| 10/9/2021 | Lawrence (2-7,1-7) | 24 | at | Cornell IA | 35 | |||
| 10/16/2021 | Chicago (8-2,7-2) | 47 | at | Cornell IA | 21 | |||
| 10/23/2021 | Cornell IA | 14 | at | Monmouth IL (8-2,8-1) | 47 | |||
| 10/30/2021 | Illinois College (5-5,5-4) | 39 | at | Cornell IA | 7 | |||
| 11/6/2021 | Cornell IA | 35 | at | Knox (3-6,3-6) | 34 | |||
| 11/13/2021 | Cornell IA | 34 | at | Grinnell (2-8,2-7) | 14 |
| vs Cornell IA | vs Other Opponents | Cornell IA compared to OOs | |
| Record: | 6-4 | 46-42 | |
| Points Scored: | 29.80 | 29.23 | -0.57 |
| Points Allowed: | 20.40 | 29.09 | -8.69 |
| Margin: | 9.40 | 0.14 | -9.26 |
| Total Points: | 50.20 | 58.32 | -8.12 |