| 9/4/2021 | Monmouth IL (8-2) | 3 | at | Wartburg | 44 | MidW | ||
| 9/11/2021 | Wartburg | 18 | at | Gustavus Adolphus (8-2) | 27 | at MIA | ||
| 9/25/2021 | Coe (8-2,6-2) | 7 | at | Wartburg | 28 | |||
| 10/2/2021 | Wartburg | 24 | at | Central IA (12-1,8-0) | 49 | |||
| 10/9/2021 | Loras (4-6,4-4) | 21 | at | Wartburg | 58 | |||
| 10/16/2021 | Wartburg | 67 | at | Luther (0-10,0-8) | 0 | |||
| 10/23/2021 | Dubuque (6-4,5-3) | 7 | at | Wartburg | 27 | |||
| 10/30/2021 | Wartburg | 20 | at | Buena Vista (5-5,4-4) | 24 | |||
| 11/6/2021 | Nebraska Wesleyan (4-6,2-6) | 14 | at | Wartburg | 50 | |||
| 11/13/2021 | Wartburg | 55 | at | Simpson (1-9,1-7) | 23 |
| vs Wartburg | vs Other Opponents | Wartburg compared to OOs | |
| Record: | 3-7 | 53-40 | |
| Points Scored: | 17.50 | 32.47 | 14.97 |
| Points Allowed: | 39.10 | 29.20 | 9.90 |
| Margin: | -21.60 | 3.27 | 24.87 |
| Total Points: | 56.60 | 61.67 | -5.07 |