| 9/4/2021 | Marietta (4-6) | 25 | at | Dubuque | 30 | OAC | ||
| 9/11/2021 | Dubuque | 7 | at | Wisconsin-La Crosse (9-3) | 38 | at WIAC | ||
| 9/18/2021 | Dubuque | 28 | at | Luther (0-10,0-8) | 2 | |||
| 10/2/2021 | Buena Vista (5-5,4-4) | 16 | at | Dubuque | 31 | |||
| 10/9/2021 | Dubuque | 31 | at | Nebraska Wesleyan (4-6,2-6) | 14 | |||
| 10/16/2021 | Simpson (1-9,1-7) | 28 | at | Dubuque | 41 | |||
| 10/23/2021 | Dubuque | 7 | at | Wartburg (7-3,6-2) | 27 | |||
| 10/30/2021 | Coe (8-2,6-2) | 34 | at | Dubuque | 27 | |||
| 11/6/2021 | Dubuque | 7 | at | Central IA (12-1,8-0) | 56 | |||
| 11/13/2021 | Loras (4-6,4-4) | 14 | at | Dubuque | 17 |
| vs Dubuque | vs Other Opponents | Dubuque compared to OOs | |
| Record: | 4-6 | 50-45 | |
| Points Scored: | 25.40 | 32.55 | 7.15 |
| Points Allowed: | 22.60 | 30.23 | -7.63 |
| Margin: | 2.80 | 2.32 | -0.48 |
| Total Points: | 48.00 | 62.78 | -14.78 |