| 9/4/2021 | Central IA | 46 | at | St Olaf (5-5) | 27 | at MIA | ||
| 9/11/2021 | Kalamazoo (1-9) | 13 | at | Central IA | 69 | MIAA | ||
| 9/18/2021 | Nebraska Wesleyan (4-6,2-6) | 7 | at | Central IA | 37 | |||
| 9/25/2021 | Central IA | 84 | at | Simpson (1-9,1-7) | 16 | |||
| 10/2/2021 | Wartburg (7-3,6-2) | 24 | at | Central IA | 49 | |||
| 10/9/2021 | Central IA | 55 | at | Coe (8-2,6-2) | 21 | |||
| 10/23/2021 | Loras (4-6,4-4) | 19 | at | Central IA | 53 | |||
| 10/30/2021 | Central IA | 76 | at | Luther (0-10,0-8) | 13 | |||
| 11/6/2021 | Dubuque (6-4,5-3) | 7 | at | Central IA | 56 | |||
| 11/13/2021 | Central IA | 65 | at | Buena Vista (5-5,4-4) | 6 | |||
| 11/20/2021 | Bethel MN (8-3) | 35 | at | Central IA | 61 | MIA | ||
| 11/27/2021 | Wheaton (10-2) | 28 | at | Central IA | 30 | CCIW | ||
| 12/4/2021 | Central IA | 21 | at | Wisconsin-Whitewater (13-1) | 51 | at WIAC |
| vs Central IA | vs Other Opponents | Central IA compared to OOs | |
| Record: | 1-12 | 71-53 | |
| Points Scored: | 20.54 | 30.90 | 10.36 |
| Points Allowed: | 54.00 | 25.37 | 28.63 |
| Margin: | -33.46 | 5.53 | 38.99 |
| Total Points: | 74.54 | 56.27 | 18.27 |