| 9/4/2021 | Luther | 14 | at | Wisconsin-Eau Claire (3-7) | 45 | at WIAC | ||
| 9/11/2021 | St Olaf (5-5) | 19 | at | Luther | 7 | MIA | ||
| 9/18/2021 | Dubuque (6-4,5-3) | 28 | at | Luther | 2 | |||
| 9/25/2021 | Luther | 14 | at | Buena Vista (5-5,4-4) | 32 | |||
| 10/2/2021 | Nebraska Wesleyan (4-6,2-6) | 28 | at | Luther | 21 | |||
| 10/9/2021 | Luther | 34 | at | Simpson (1-9,1-7) | 68 | |||
| 10/16/2021 | Wartburg (7-3,6-2) | 67 | at | Luther | 0 | |||
| 10/23/2021 | Luther | 7 | at | Coe (8-2,6-2) | 63 | |||
| 10/30/2021 | Central IA (12-1,8-0) | 76 | at | Luther | 13 | |||
| 11/6/2021 | Luther | 6 | at | Loras (4-6,4-4) | 69 |
| vs Luther | vs Other Opponents | Luther compared to OOs | |
| Record: | 10-0 | 45-48 | |
| Points Scored: | 49.50 | 29.74 | -19.76 |
| Points Allowed: | 11.80 | 31.28 | -19.48 |
| Margin: | 37.70 | -1.54 | -39.24 |
| Total Points: | 61.30 | 61.02 | 0.28 |