| 9/2/2021 | Dickinson State (8-3) | 24 | at | Black Hills State | 30 | NSAA (NAIA) | ||
| 9/11/2021 | Black Hills State | 31 | at | William Jewell (0-11) | 21 | at GLV | ||
| 9/18/2021 | Black Hills State | 16 | at | Colorado State-Pueblo (6-5,6-3) | 19 | |||
| 9/25/2021 | Adams State (1-10,1-8) | 48 | at | Black Hills State | 51 | 2OT | ||
| 10/2/2021 | Black Hills State | 45 | at | Fort Lewis (0-11,0-9) | 17 | |||
| 10/9/2021 | Colorado Mines (12-2,8-1) | 41 | at | Black Hills State | 20 | |||
| 10/16/2021 | Black Hills State | 28 | at | Western Colorado (10-2,8-1) | 44 | |||
| 10/23/2021 | New Mexico Highlands (4-6,4-5) | 24 | at | Black Hills State | 10 | |||
| 10/30/2021 | South Dakota Tech (6-5,4-5) | 13 | at | Black Hills State | 10 | |||
| 11/6/2021 | Black Hills State | 9 | at | Colorado Mesa (8-2,7-2) | 52 | |||
| 11/13/2021 | Chadron State (6-5,5-4) | 57 | at | Black Hills State | 6 |
| vs Black Hills State | vs Other Opponents | Black Hills State compared to OOs | |
| Record: | 7-4 | 54-58 | |
| Points Scored: | 32.73 | 28.02 | -4.71 |
| Points Allowed: | 23.27 | 27.63 | -4.36 |
| Margin: | 9.46 | 0.39 | -9.07 |
| Total Points: | 56.00 | 55.65 | 0.35 |