| 9/2/2021 | William Jewell (0-11) | 3 | at | Colorado Mesa | 40 | GLV | ||
| 9/18/2021 | Colorado Mesa | 56 | at | New Mexico Highlands (4-6,4-5) | 37 | |||
| 9/25/2021 | Chadron State (6-5,5-4) | 17 | at | Colorado Mesa | 24 | |||
| 10/2/2021 | Colorado Mesa | 13 | at | Colorado State-Pueblo (6-5,6-3) | 19 | |||
| 10/9/2021 | Adams State (1-10,1-8) | 14 | at | Colorado Mesa | 49 | |||
| 10/16/2021 | Colorado Mesa | 55 | at | Fort Lewis (0-11,0-9) | 3 | |||
| 10/23/2021 | Colorado Mines (12-2,8-1) | 21 | at | Colorado Mesa | 26 | |||
| 10/30/2021 | Colorado Mesa | 9 | at | Western Colorado (10-2,8-1) | 23 | |||
| 11/6/2021 | Black Hills State (4-7,2-7) | 9 | at | Colorado Mesa | 52 | |||
| 11/13/2021 | Colorado Mesa | 13 | at | South Dakota Tech (6-5,4-5) | 10 |
| vs Colorado Mesa | vs Other Opponents | Colorado Mesa compared to OOs | |
| Record: | 2-8 | 47-56 | |
| Points Scored: | 15.60 | 27.46 | 11.86 |
| Points Allowed: | 33.70 | 29.34 | 4.36 |
| Margin: | -18.10 | -1.88 | 16.22 |
| Total Points: | 49.30 | 56.80 | -7.50 |