| 9/5/2021 | Fort Valley State (5-5,5-4) | 30 | vs | Tuskegee | 0 | Montgomery AL | ||
| 9/11/2021 | West Alabama (7-4) | 33 | at | Tuskegee | 7 | GSC | ||
| 9/18/2021 | Edward Waters (4-7,3-7) | 6 | at | Tuskegee | 23 | |||
| 9/25/2021 | Tuskegee | 35 | vs | Alabama A&M (7-3) | 45 | Mobile AL | vs SWAC | |
| 10/2/2021 | Clark Atlanta (2-8,1-7) | 0 | at | Tuskegee | 21 | |||
| 10/9/2021 | Tuskegee | 15 | vs | Morehouse (4-6,4-4) | 31 | Birmingham AL | ||
| 10/16/2021 | Tuskegee | 29 | at | Central State (1-9,0-8) | 0 | |||
| 10/23/2021 | Lane (6-4,5-3) | 21 | at | Tuskegee | 17 | |||
| 10/30/2021 | Kentucky State (7-4,6-2) | 42 | at | Tuskegee | 35 | |||
| 11/6/2021 | Tuskegee | 23 | at | Miles (6-5,6-3) | 52 | |||
| 11/25/2021 | Tuskegee | 9 | at | Alabama State (5-6) | 43 | at SWAC |
| vs Tuskegee | vs Other Opponents | Tuskegee compared to OOs | |
| Record: | 8-3 | 46-58 | |
| Points Scored: | 27.55 | 25.11 | -2.44 |
| Points Allowed: | 19.45 | 28.74 | -9.29 |
| Margin: | 8.10 | -3.63 | -11.73 |
| Total Points: | 47.00 | 53.85 | -6.85 |