| 8/28/2021 | Kentucky State | 20 | vs | Central State (1-9,0-8) | 6 | Columbus OH | ||
| 9/11/2021 | Kentucky Wesleyan (3-8) | 26 | at | Kentucky State | 25 | GMAC | ||
| 9/18/2021 | Kentucky State | 7 | at | Tennessee State (5-6) | 41 | at OVC | ||
| 9/25/2021 | Benedict (5-5,5-5) | 28 | at | Kentucky State | 34 | |||
| 10/2/2021 | Savannah State (8-2,6-1) | 21 | at | Kentucky State | 17 | |||
| 10/9/2021 | Lane (6-4,5-3) | 14 | at | Kentucky State | 49 | |||
| 10/16/2021 | Kentucky State | 76 | at | Edward Waters (4-7,3-7) | 36 | |||
| 10/23/2021 | Miles (6-5,6-3) | 28 | at | Kentucky State | 21 | |||
| 10/30/2021 | Kentucky State | 42 | at | Tuskegee (3-8,3-5) | 35 | |||
| 11/6/2021 | Central State (1-9,0-8) | 0 | at | Kentucky State | 63 | |||
| 11/13/2021 | Kentucky State | 41 | at | Erskine (3-8) | 17 | at D2Ind |
| vs Kentucky State | vs Other Opponents | Kentucky State compared to OOs | |
| Record: | 4-7 | 41-62 | |
| Points Scored: | 22.91 | 22.22 | -0.69 |
| Points Allowed: | 35.91 | 28.58 | 7.33 |
| Margin: | -13.00 | -6.36 | 6.64 |
| Total Points: | 58.82 | 50.80 | 8.02 |