| 9/4/2021 | Miles | 13 | at | Alabama State (5-6) | 14 | OT | at SWAC | |
| 9/11/2021 | Miles | 24 | at | Southern (4-7) | 41 | at SWAC | ||
| 9/18/2021 | Miles | 37 | at | Morehouse (4-6,4-4) | 14 | |||
| 9/25/2021 | Central State (1-9,0-8) | 4 | at | Miles | 55 | |||
| 10/2/2021 | Albany State GA (10-2,8-0) | 31 | at | Miles | 3 | |||
| 10/9/2021 | Benedict (5-5,5-5) | 24 | at | Miles | 21 | |||
| 10/16/2021 | Miles | 34 | at | Lane (6-4,5-3) | 31 | |||
| 10/23/2021 | Miles | 28 | at | Kentucky State (7-4,6-2) | 21 | |||
| 10/30/2021 | Miles | 16 | at | Edward Waters (4-7,3-7) | 9 | |||
| 11/6/2021 | Tuskegee (3-8,3-5) | 23 | at | Miles | 52 | |||
| 11/13/2021 | Albany State GA (10-2,8-0) | 31 | at | Miles | 0 |
| vs Miles | vs Other Opponents | Miles compared to OOs | |
| Record: | 5-6 | 52-54 | |
| Points Scored: | 22.09 | 25.30 | 3.21 |
| Points Allowed: | 25.73 | 24.11 | 1.62 |
| Margin: | -3.64 | 1.19 | 4.83 |
| Total Points: | 47.82 | 49.41 | -1.59 |