D2
11 Jan 2022 16:14:08
| 8/28/2021 | Kentucky State | 20 | vs | Central State | 6 | | Columbus OH | |
| Florida Memorial | 20 | at | Edward Waters | 24 | | | MSC (NAIA) |
| 9/2/2021 | Albany State GA | 24 | at | Mississippi College | 0 | | | @ GSC |
| 9/4/2021 | Miles | 13 | at | Alabama State | 14 | OT | | @ SWAC (1AA) |
| Lane | 16 | at | Ark Pine Bluff | 34 | | | @ SWAC (1AA) |
| Allen | 12 | at | Benedict | 45 | | | |
| Clark Atlanta | 13 | at | Livingstone | 10 | | | @ CIAA |
| Savannah State | 7 | at | Valdosta State | 53 | | | @ GSC |
| Morehouse | 7 | at | West Alabama | 48 | | | @ GSC |
| 9/5/2021 | Fort Valley State | 30 | vs | Tuskegee | 0 | | Montgomery AL | |
| 9/9/2021 | Edward Waters | 3 | at | Benedict | 44 | | | |
| 9/11/2021 | Shorter | 12 | at | Albany State GA | 28 | | | GSC |
| Lane | 35 | at | Clark Atlanta | 26 | | | |
| Fort Valley State | 7 | at | Florida A&M | 34 | | | @ SWAC (1AA) |
| Allen | 20 | at | Johnson C Smith | 19 | | | @ CIAA |
| Kentucky Wesleyan | 26 | at | Kentucky State | 25 | | | GMAC |
| Central State | 19 | at | Lincoln PA | 7 | | | @ CIAA |
| Livingstone | 6 | at | Savannah State | 50 | | | CIAA |
| Miles | 24 | at | Southern | 41 | | | @ SWAC (1AA) |
| West Alabama | 33 | at | Tuskegee | 7 | | | GSC |
| Morehouse | 0 | at | West Georgia | 47 | | | @ GSC |
| 9/18/2021 | Livingstone | 32 | at | Allen | 34 | | | CIAA |
| Shorter | 38 | at | Clark Atlanta | 17 | | | GSC |
| Lane | 27 | at | Fort Valley State | 24 | | | |
| Miles | 37 | at | Morehouse | 14 | | | |
| Benedict | 34 | at | Savannah State | 41 | | | |
| Central State | 0 | at | Shaw | 52 | | | @ CIAA |
| Kentucky State | 7 | at | Tennessee State | 41 | | | @ OVC (1AA) |
| Edward Waters | 6 | at | Tuskegee | 23 | | | |
| Albany State GA | 3 | at | Valdosta State | 21 | | | @ GSC |
| 9/25/2021 | Tuskegee | 35 | vs | Alabama A&M | 45 | | Mobile AL | vs SWAC (1AA) |
| Clark Atlanta | 0 | at | Albany State GA | 49 | | | |
| Fort Valley State | 56 | at | Allen | 20 | | | |
| Lane | 45 | at | Edward Waters | 35 | | | |
| Benedict | 28 | at | Kentucky State | 34 | | | |
| Central State | 4 | at | Miles | 55 | | | |
| Morehouse | 10 | at | Savannah State | 29 | | | |
| 10/2/2021 | Fort Valley State | 24 | at | Benedict | 14 | | | |
| Allen | 46 | at | Central State | 34 | | | |
| Savannah State | 21 | at | Kentucky State | 17 | | | |
| Texas College | 0 | at | Lane | 71 | | | Soon (NAIA) |
| Albany State GA | 31 | at | Miles | 3 | | | |
| Edward Waters | 37 | at | Morehouse | 13 | | | |
| Clark Atlanta | 0 | at | Tuskegee | 21 | | | |
| 10/9/2021 | Edward Waters | 0 | at | Albany State GA | 30 | | | |
| Allen | 12 | at | Clark Atlanta | 21 | | | |
| Central State | 14 | at | Fort Valley State | 35 | | | |
| Lane | 14 | at | Kentucky State | 49 | | | |
| Benedict | 24 | at | Miles | 21 | | | |
| Tuskegee | 15 | vs | Morehouse | 31 | | Birmingham AL | |
| Erskine | 6 | at | Savannah State | 39 | | | D2Ind |
| 10/16/2021 | Albany State GA | 28 | at | Benedict | 6 | | | |
| Tuskegee | 29 | at | Central State | 0 | | | |
| Kentucky State | 76 | at | Edward Waters | 36 | | | |
| Miles | 34 | at | Lane | 31 | | | |
| Fort Valley State | 3 | at | Morehouse | 51 | | | |
| Clark Atlanta | 14 | at | Savannah State | 49 | | | |
| 10/23/2021 | Savannah State | 0 | at | Albany State GA | 30 | | | |
| Morehouse | 20 | at | Benedict | 5 | | | |
| Central State | 19 | at | Edward Waters | 56 | | | |
| Allen | 40 | at | Erskine | 47 | | | @ D2Ind |
| Clark Atlanta | 7 | at | Fort Valley State | 40 | | | |
| Miles | 28 | at | Kentucky State | 21 | | | |
| Lane | 21 | at | Tuskegee | 17 | | | |
| 10/30/2021 | Lane | 16 | at | Central State | 14 | | | |
| Benedict | 24 | at | Clark Atlanta | 21 | | | |
| Miles | 16 | at | Edward Waters | 9 | | | |
| Savannah State | 24 | at | Fort Valley State | 6 | | | |
| Albany State GA | 14 | at | Morehouse | 10 | | | |
| Kentucky State | 42 | at | Tuskegee | 35 | | | |
| 11/6/2021 | Lane | 30 | at | Benedict | 34 | | | |
| Morehouse | 35 | at | Clark Atlanta | 26 | | | |
| Albany State GA | 57 | vs | Fort Valley State | 0 | | Columbus GA | |
| Central State | 0 | at | Kentucky State | 63 | | | |
| Tuskegee | 23 | at | Miles | 52 | | | |
| Edward Waters | 0 | at | Savannah State | 24 | | | |
| 11/13/2021 | Edward Waters | 51 | at | Allen | 34 | | | |
| Kentucky State | 41 | at | Erskine | 17 | | | @ D2Ind |
| Albany State GA | 31 | at | Miles | 0 | | | |
| 11/20/2021 | West Georgia | 23 | at | Albany State GA | 7 | | | GSC |
| 11/25/2021 | Tuskegee | 9 | at | Alabama State | 43 | | | @ SWAC (1AA) |