| 8/28/2021 | Florida Memorial (2-9) | 20 | at | Edward Waters | 24 | MSC (NAIA) | ||
| 9/9/2021 | Edward Waters | 3 | at | Benedict (5-5,5-5) | 44 | |||
| 9/18/2021 | Edward Waters | 6 | at | Tuskegee (3-8,3-5) | 23 | |||
| 9/25/2021 | Lane (6-4,5-3) | 45 | at | Edward Waters | 35 | |||
| 10/2/2021 | Edward Waters | 37 | at | Morehouse (4-6,4-4) | 13 | |||
| 10/9/2021 | Edward Waters | 0 | at | Albany State GA (10-2,8-0) | 30 | |||
| 10/16/2021 | Kentucky State (7-4,6-2) | 76 | at | Edward Waters | 36 | |||
| 10/23/2021 | Central State (1-9,0-8) | 19 | at | Edward Waters | 56 | |||
| 10/30/2021 | Miles (6-5,6-3) | 16 | at | Edward Waters | 9 | |||
| 11/6/2021 | Edward Waters | 0 | at | Savannah State (8-2,6-1) | 24 | |||
| 11/13/2021 | Edward Waters | 51 | at | Allen (3-5,1-4) | 34 |
| vs Edward Waters | vs Other Opponents | Edward Waters compared to OOs | |
| Record: | 7-4 | 48-55 | |
| Points Scored: | 31.27 | 23.74 | -7.53 |
| Points Allowed: | 23.36 | 25.10 | -1.74 |
| Margin: | 7.91 | -1.36 | -9.27 |
| Total Points: | 54.63 | 48.84 | 5.79 |