| 9/4/2021 | Clark Atlanta | 13 | at | Livingstone (1-8) | 10 | at CIAA | ||
| 9/11/2021 | Lane (6-4,5-3) | 35 | at | Clark Atlanta | 26 | |||
| 9/18/2021 | Shorter (3-8) | 38 | at | Clark Atlanta | 17 | GSC | ||
| 9/25/2021 | Clark Atlanta | 0 | at | Albany State GA (10-2,8-0) | 49 | |||
| 10/2/2021 | Clark Atlanta | 0 | at | Tuskegee (3-8,3-5) | 21 | |||
| 10/9/2021 | Allen (3-5,1-4) | 12 | at | Clark Atlanta | 21 | |||
| 10/16/2021 | Clark Atlanta | 14 | at | Savannah State (8-2,6-1) | 49 | |||
| 10/23/2021 | Clark Atlanta | 7 | at | Fort Valley State (5-5,5-4) | 40 | |||
| 10/30/2021 | Benedict (5-5,5-5) | 24 | at | Clark Atlanta | 21 | |||
| 11/6/2021 | Morehouse (4-6,4-4) | 35 | at | Clark Atlanta | 26 |
| vs Clark Atlanta | vs Other Opponents | Clark Atlanta compared to OOs | |
| Record: | 8-2 | 40-51 | |
| Points Scored: | 31.30 | 21.92 | -9.38 |
| Points Allowed: | 14.50 | 25.51 | -11.01 |
| Margin: | 16.80 | -3.59 | -20.39 |
| Total Points: | 45.80 | 47.43 | -1.63 |