| 8/28/2021 | Kentucky State (7-4,6-2) | 20 | vs | Central State | 6 | Columbus OH | ||
| 9/11/2021 | Central State | 19 | at | Lincoln PA (1-9) | 7 | at CIAA | ||
| 9/18/2021 | Central State | 0 | at | Shaw (6-4) | 52 | at CIAA | ||
| 9/25/2021 | Central State | 4 | at | Miles (6-5,6-3) | 55 | |||
| 10/2/2021 | Allen (3-5,1-4) | 46 | at | Central State | 34 | |||
| 10/9/2021 | Central State | 14 | at | Fort Valley State (5-5,5-4) | 35 | |||
| 10/16/2021 | Tuskegee (3-8,3-5) | 29 | at | Central State | 0 | |||
| 10/23/2021 | Central State | 19 | at | Edward Waters (4-7,3-7) | 56 | |||
| 10/30/2021 | Lane (6-4,5-3) | 16 | at | Central State | 14 | |||
| 11/6/2021 | Central State | 0 | at | Kentucky State (7-4,6-2) | 63 |
| vs Central State | vs Other Opponents | Central State compared to OOs | |
| Record: | 9-1 | 37-54 | |
| Points Scored: | 37.90 | 24.56 | -13.34 |
| Points Allowed: | 11.00 | 28.11 | -17.11 |
| Margin: | 26.90 | -3.55 | -30.45 |
| Total Points: | 48.90 | 52.67 | -3.77 |