| 9/2/2021 | Missouri S&T (6-5) | 31 | at | South Dakota Tech | 34 | GLV | ||
| 9/11/2021 | Mayville State (2-9) | 7 | at | South Dakota Tech | 52 | NSAA (NAIA) | ||
| 9/18/2021 | South Dakota Tech | 20 | at | Chadron State (6-5,5-4) | 31 | |||
| 9/25/2021 | Colorado State-Pueblo (6-5,6-3) | 49 | at | South Dakota Tech | 7 | |||
| 10/2/2021 | South Dakota Tech | 45 | at | Adams State (1-10,1-8) | 42 | |||
| 10/9/2021 | Fort Lewis (0-11,0-9) | 7 | at | South Dakota Tech | 42 | |||
| 10/16/2021 | South Dakota Tech | 24 | at | Colorado Mines (12-2,8-1) | 44 | |||
| 10/23/2021 | Western Colorado (10-2,8-1) | 42 | at | South Dakota Tech | 21 | |||
| 10/30/2021 | South Dakota Tech | 13 | at | Black Hills State (4-7,2-7) | 10 | |||
| 11/6/2021 | South Dakota Tech | 40 | at | New Mexico Highlands (4-6,4-5) | 17 | |||
| 11/13/2021 | Colorado Mesa (8-2,7-2) | 13 | at | South Dakota Tech | 10 |
| vs South Dakota Tech | vs Other Opponents | South Dakota Tech compared to OOs | |
| Record: | 5-6 | 54-58 | |
| Points Scored: | 26.64 | 28.74 | 2.10 |
| Points Allowed: | 28.00 | 28.50 | -0.50 |
| Margin: | -1.36 | 0.24 | 1.60 |
| Total Points: | 54.64 | 57.24 | -2.60 |