| 8/28/2021 | Mayville State | 32 | at | Roosevelt (4-4) | 37 | at MSFA | ||
| 9/4/2021 | Wisconsin-Stevens Point (2-8) | 31 | at | Mayville State | 14 | WIAC (D3) | ||
| 9/11/2021 | Mayville State | 7 | at | South Dakota Tech (6-5) | 52 | at RMAC | ||
| 9/18/2021 | Dickinson State (8-3,7-0) | 51 | at | Mayville State | 13 | |||
| 9/25/2021 | Mayville State | 16 | at | Dakota State (6-4,4-3) | 20 | |||
| 10/2/2021 | Mayville State | 0 | at | Valley City State (8-2,5-2) | 49 | |||
| 10/9/2021 | Waldorf (7-3,4-3) | 52 | at | Mayville State | 51 | |||
| 10/16/2021 | Presentation (0-11,0-7) | 27 | at | Mayville State | 49 | |||
| 10/23/2021 | Mayville State | 19 | at | Waldorf (7-3,4-3) | 39 | |||
| 10/30/2021 | Mayville State | 7 | at | Dickinson State (8-3,7-0) | 53 | |||
| 11/11/2021 | Iowa Wesleyan (2-9) | 14 | at | Mayville State | 42 | NAIAInd |
| vs Mayville State | vs Other Opponents | Mayville State compared to OOs | |
| Record: | 9-2 | 45-53 | |
| Points Scored: | 38.64 | 26.13 | -12.51 |
| Points Allowed: | 22.73 | 27.48 | -4.75 |
| Margin: | 15.91 | -1.35 | -17.26 |
| Total Points: | 61.37 | 53.61 | 7.76 |