| 9/2/2021 | Western Oregon (4-6) | 3 | at | Colorado Mines | 42 | GNWAC | ||
| 9/11/2021 | New Mexico Highlands (4-6,4-5) | 21 | at | Colorado Mines | 31 | |||
| 9/18/2021 | Colorado Mines | 76 | at | Fort Lewis (0-11,0-9) | 0 | |||
| 9/25/2021 | Colorado Mines | 21 | at | West Texas A&M (7-4) | 13 | at LSC | ||
| 10/2/2021 | Western Colorado (10-2,8-1) | 14 | at | Colorado Mines | 20 | OT | ||
| 10/9/2021 | Colorado Mines | 41 | at | Black Hills State (4-7,2-7) | 20 | |||
| 10/16/2021 | South Dakota Tech (6-5,4-5) | 24 | at | Colorado Mines | 44 | |||
| 10/23/2021 | Colorado Mines | 21 | at | Colorado Mesa (8-2,7-2) | 26 | |||
| 10/30/2021 | Chadron State (6-5,5-4) | 7 | at | Colorado Mines | 34 | |||
| 11/6/2021 | Colorado Mines | 28 | at | Colorado State-Pueblo (6-5,6-3) | 12 | |||
| 11/13/2021 | Adams State (1-10,1-8) | 0 | at | Colorado Mines | 63 | |||
| 11/27/2021 | Bemidji State (10-3) | 6 | at | Colorado Mines | 55 | NSIC | ||
| 12/4/2021 | Angelo State (11-3) | 26 | at | Colorado Mines | 34 | LSC | ||
| 12/11/2021 | Colorado Mines | 31 | at | Valdosta State (12-2) | 34 | D2 Semifinal | at GSC |
| vs Colorado Mines | vs Other Opponents | Colorado Mines compared to OOs | |
| Record: | 2-12 | 87-59 | |
| Points Scored: | 14.71 | 31.19 | 16.48 |
| Points Allowed: | 38.64 | 25.65 | 12.99 |
| Margin: | -23.93 | 5.54 | 29.47 |
| Total Points: | 53.35 | 56.84 | -3.49 |