| 9/2/2021 | Texas A&M-Commerce (7-4) | 12 | at | Colorado State-Pueblo | 6 | LSC | ||
| 9/11/2021 | Colorado State-Pueblo | 14 | at | Grand Valley State (10-2) | 34 | at GLIAC | ||
| 9/18/2021 | Black Hills State (4-7,2-7) | 16 | at | Colorado State-Pueblo | 19 | |||
| 9/25/2021 | Colorado State-Pueblo | 49 | at | South Dakota Tech (6-5,4-5) | 7 | |||
| 10/2/2021 | Colorado Mesa (8-2,7-2) | 13 | at | Colorado State-Pueblo | 19 | |||
| 10/9/2021 | Colorado State-Pueblo | 42 | at | Chadron State (6-5,5-4) | 17 | |||
| 10/16/2021 | Colorado State-Pueblo | 21 | at | New Mexico Highlands (4-6,4-5) | 28 | |||
| 10/23/2021 | Adams State (1-10,1-8) | 28 | at | Colorado State-Pueblo | 35 | |||
| 10/30/2021 | Colorado State-Pueblo | 73 | at | Fort Lewis (0-11,0-9) | 0 | |||
| 11/6/2021 | Colorado Mines (12-2,8-1) | 28 | at | Colorado State-Pueblo | 12 | |||
| 11/13/2021 | Colorado State-Pueblo | 7 | at | Western Colorado (10-2,8-1) | 14 |
| vs Colorado State-Pueblo | vs Other Opponents | Colorado State-Pueblo compared to OOs | |
| Record: | 5-6 | 63-50 | |
| Points Scored: | 17.91 | 30.67 | 12.76 |
| Points Allowed: | 27.00 | 25.69 | 1.31 |
| Margin: | -9.09 | 4.98 | 14.07 |
| Total Points: | 44.91 | 56.36 | -11.45 |