| 9/4/2021 | Chadron State | 10 | at | Western Colorado (10-2,8-1) | 23 | |||
| 9/11/2021 | Angelo State (11-3) | 28 | at | Chadron State | 24 | LSC | ||
| 9/18/2021 | South Dakota Tech (6-5,4-5) | 20 | at | Chadron State | 31 | |||
| 9/25/2021 | Chadron State | 17 | at | Colorado Mesa (8-2,7-2) | 24 | |||
| 10/2/2021 | Chadron State | 46 | at | New Mexico Highlands (4-6,4-5) | 16 | |||
| 10/9/2021 | Colorado State-Pueblo (6-5,6-3) | 42 | at | Chadron State | 17 | |||
| 10/16/2021 | Chadron State | 45 | at | Adams State (1-10,1-8) | 35 | |||
| 10/23/2021 | Fort Lewis (0-11,0-9) | 7 | at | Chadron State | 60 | |||
| 10/30/2021 | Chadron State | 7 | at | Colorado Mines (12-2,8-1) | 34 | |||
| 11/6/2021 | Western Oregon (4-6) | 7 | at | Chadron State | 45 | GNWAC | ||
| 11/13/2021 | Chadron State | 57 | at | Black Hills State (4-7,2-7) | 6 |
| vs Chadron State | vs Other Opponents | Chadron State compared to OOs | |
| Record: | 5-6 | 61-53 | |
| Points Scored: | 22.00 | 28.94 | 6.94 |
| Points Allowed: | 32.64 | 25.84 | 6.80 |
| Margin: | -10.64 | 3.10 | 13.74 |
| Total Points: | 54.64 | 54.78 | -0.14 |