| 9/4/2021 | Western New Mexico (1-9) | 35 | at | Adams State | 17 | LSC | ||
| 9/11/2021 | Adams State | 14 | at | Eastern New Mexico (4-7) | 42 | at LSC | ||
| 9/18/2021 | Western Colorado (10-2,8-1) | 24 | at | Adams State | 10 | |||
| 9/25/2021 | Adams State | 48 | at | Black Hills State (4-7,2-7) | 51 | 2OT | ||
| 10/2/2021 | South Dakota Tech (6-5,4-5) | 45 | at | Adams State | 42 | |||
| 10/9/2021 | Adams State | 14 | at | Colorado Mesa (8-2,7-2) | 49 | |||
| 10/16/2021 | Chadron State (6-5,5-4) | 45 | at | Adams State | 35 | |||
| 10/23/2021 | Adams State | 28 | at | Colorado State-Pueblo (6-5,6-3) | 35 | |||
| 10/30/2021 | Adams State | 28 | at | New Mexico Highlands (4-6,4-5) | 58 | |||
| 11/6/2021 | Fort Lewis (0-11,0-9) | 14 | at | Adams State | 37 | |||
| 11/13/2021 | Adams State | 0 | at | Colorado Mines (12-2,8-1) | 63 |
| vs Adams State | vs Other Opponents | Adams State compared to OOs | |
| Record: | 10-1 | 51-60 | |
| Points Scored: | 41.91 | 26.70 | -15.21 |
| Points Allowed: | 24.82 | 28.16 | -3.34 |
| Margin: | 17.09 | -1.46 | -18.55 |
| Total Points: | 66.73 | 54.86 | 11.87 |