| 9/2/2021 | Walsh | 27 | at | West Liberty (4-7) | 6 | at MtnE | ||
| 9/11/2021 | Davenport (3-8) | 10 | at | Walsh | 6 | GLIAC | ||
| 9/18/2021 | Walsh | 17 | at | Quincy (4-7) | 38 | at GLV | ||
| 9/25/2021 | McKendree (4-7) | 24 | at | Walsh | 10 | GLV | ||
| 9/30/2021 | Ashland (5-5,4-3) | 35 | at | Walsh | 10 | |||
| 10/9/2021 | Walsh | 3 | at | Hillsdale (6-6,5-2) | 20 | |||
| 10/16/2021 | Kentucky Wesleyan (3-8,1-6) | 23 | at | Walsh | 13 | |||
| 10/23/2021 | Walsh | 17 | at | Ohio Dominican (7-4,4-3) | 56 | |||
| 10/30/2021 | Findlay (8-4,6-1) | 49 | at | Walsh | 0 | |||
| 11/6/2021 | Tiffin (8-3,5-2) | 56 | at | Walsh | 16 | |||
| 11/13/2021 | Walsh | 24 | at | Lake Erie (5-6,2-5) | 7 |
| vs Walsh | vs Other Opponents | Walsh compared to OOs | |
| Record: | 9-2 | 48-63 | |
| Points Scored: | 29.45 | 25.41 | -4.04 |
| Points Allowed: | 13.00 | 28.73 | -15.73 |
| Margin: | 16.45 | -3.32 | -19.77 |
| Total Points: | 42.45 | 54.14 | -11.69 |