| 9/4/2021 | Northern Michigan | 27 | at | McKendree (4-7) | 20 | at GLV | ||
| 9/11/2021 | Wisconsin-Oshkosh (6-3) | 28 | at | Northern Michigan | 10 | WIAC (D3) | ||
| 9/18/2021 | Davenport (3-8,2-7) | 14 | at | Northern Michigan | 20 | |||
| 9/25/2021 | Northern Michigan | 20 | at | Northwood (1-9,1-7) | 37 | |||
| 10/2/2021 | Wayne State MI (2-9,2-6) | 19 | at | Northern Michigan | 26 | |||
| 10/9/2021 | Northern Michigan | 13 | at | Davenport (3-8,2-7) | 18 | |||
| 10/16/2021 | Michigan Tech (6-4,5-3) | 21 | at | Northern Michigan | 14 | |||
| 10/23/2021 | Grand Valley State (10-2,7-2) | 28 | at | Northern Michigan | 24 | |||
| 10/30/2021 | Northern Michigan | 24 | at | Ferris State (14-0,9-0) | 44 | |||
| 11/6/2021 | Northern Michigan | 21 | at | Saginaw Valley State (7-4,5-3) | 33 | |||
| 11/13/2021 | Northwood (1-9,1-7) | 26 | at | Northern Michigan | 34 |
| vs Northern Michigan | vs Other Opponents | Northern Michigan compared to OOs | |
| Record: | 7-4 | 48-57 | |
| Points Scored: | 26.18 | 26.31 | 0.13 |
| Points Allowed: | 21.18 | 28.96 | -7.78 |
| Margin: | 5.00 | -2.65 | -7.65 |
| Total Points: | 47.36 | 55.27 | -7.91 |