| 9/2/2021 | Angelo State | 40 | at | Lindenwood (9-3) | 20 | at MAIAA | ||
| 9/11/2021 | Angelo State | 28 | at | Chadron State (6-5) | 24 | at RMAC | ||
| 9/18/2021 | Midwestern State (7-3,6-1) | 35 | at | Angelo State | 17 | |||
| 9/25/2021 | Angelo State | 14 | at | Central Washington (8-3) | 9 | at GNWAC | ||
| 10/2/2021 | Western New Mexico (1-9,0-7) | 3 | at | Angelo State | 62 | |||
| 10/9/2021 | Angelo State | 15 | at | West Texas A&M (7-4,5-2) | 31 | |||
| 10/16/2021 | Texas-Permian Basin (5-6,3-4) | 14 | at | Angelo State | 34 | |||
| 10/23/2021 | Simon Fraser (1-7) | 10 | at | Angelo State | 51 | GNWAC | ||
| 10/30/2021 | Angelo State | 59 | at | Eastern New Mexico (4-7,1-6) | 7 | |||
| 11/6/2021 | Texas A&M-Commerce (7-4,5-2) | 3 | at | Angelo State | 30 | |||
| 11/13/2021 | Angelo State | 58 | at | Texas A&M-Kingsville (5-5,3-4) | 19 | |||
| 11/20/2021 | Minnesota-Duluth (9-3) | 14 | at | Angelo State | 48 | NSIC | ||
| 11/27/2021 | Nebraska-Kearney (10-3) | 7 | at | Angelo State | 20 | MAIAA | ||
| 12/4/2021 | Angelo State | 26 | at | Colorado Mines (12-2) | 34 | at RMAC |
| vs Angelo State | vs Other Opponents | Angelo State compared to OOs | |
| Record: | 3-11 | 88-53 | |
| Points Scored: | 16.43 | 32.32 | 15.89 |
| Points Allowed: | 35.86 | 24.21 | 11.65 |
| Margin: | -19.43 | 8.11 | 27.54 |
| Total Points: | 52.29 | 56.53 | -4.24 |