| 9/2/2021 | Gannon (5-6) | 28 | at | Northwood | 21 | OT | PSAC | |
| 9/11/2021 | Northwood | 6 | at | Tiffin (8-3) | 40 | at GMAC | ||
| 9/25/2021 | Northern Michigan (4-7,3-6) | 20 | at | Northwood | 37 | |||
| 10/2/2021 | Ferris State (14-0,9-0) | 67 | at | Northwood | 25 | |||
| 10/9/2021 | Northwood | 9 | at | Grand Valley State (10-2,7-2) | 70 | |||
| 10/16/2021 | Northwood | 13 | at | Saginaw Valley State (7-4,5-3) | 31 | |||
| 10/23/2021 | Davenport (3-8,2-7) | 21 | at | Northwood | 14 | |||
| 10/30/2021 | Northwood | 21 | at | Wayne State MI (2-9,2-6) | 56 | |||
| 11/6/2021 | Michigan Tech (6-4,5-3) | 34 | at | Northwood | 0 | |||
| 11/13/2021 | Northwood | 26 | at | Northern Michigan (4-7,3-6) | 34 |
| vs Northwood | vs Other Opponents | Northwood compared to OOs | |
| Record: | 9-1 | 53-48 | |
| Points Scored: | 40.10 | 26.45 | -13.65 |
| Points Allowed: | 17.20 | 24.88 | -7.68 |
| Margin: | 22.90 | 1.57 | -21.33 |
| Total Points: | 57.30 | 51.33 | 5.97 |