| 9/2/2021 | Incarnate Word (10-3) | 41 | at | Youngstown State | 44 | OT | SLC | |
| 9/11/2021 | Youngstown State | 14 | at | Michigan State (11-2) | 42 | at B10 | ||
| 9/25/2021 | Western Illinois (2-9,2-6) | 38 | at | Youngstown State | 35 | |||
| 10/2/2021 | Youngstown State | 7 | at | Northern Iowa (6-6,4-4) | 34 | |||
| 10/9/2021 | Missouri State (8-4,6-2) | 33 | at | Youngstown State | 41 | |||
| 10/23/2021 | Youngstown State | 17 | at | Indiana State (5-6,3-5) | 28 | |||
| 10/30/2021 | South Dakota State (11-4,5-3) | 47 | at | Youngstown State | 16 | |||
| 11/6/2021 | Youngstown State | 21 | at | North Dakota (5-6,3-5) | 24 | |||
| 11/13/2021 | North Dakota State (14-1,8-1) | 49 | at | Youngstown State | 17 | |||
| 11/20/2021 | Youngstown State | 35 | at | Southern Illinois (8-5,6-4) | 18 |
| vs Youngstown State | vs Other Opponents | Youngstown State compared to OOs | |
| Record: | 7-3 | 73-43 | |
| Points Scored: | 35.40 | 29.74 | -5.66 |
| Points Allowed: | 24.70 | 23.63 | 1.07 |
| Margin: | 10.70 | 6.11 | -4.59 |
| Total Points: | 60.10 | 53.37 | 6.73 |