| 9/4/2021 | Butler | 7 | at | Illinois State (4-7) | 49 | at MVC | ||
| 9/11/2021 | DePauw (9-3) | 24 | at | Butler | 49 | NCA (D3) | ||
| 9/18/2021 | Butler | 77 | at | Taylor (2-8) | 24 | at MSFA | ||
| 9/25/2021 | Butler | 0 | at | St Thomas (7-3,6-2) | 36 | |||
| 10/2/2021 | Drake (2-8,1-6) | 6 | at | Butler | 3 | |||
| 10/9/2021 | San Diego (7-4,7-1) | 52 | at | Butler | 21 | |||
| 10/16/2021 | Butler | 8 | at | Morehead State (7-4,6-2) | 31 | |||
| 10/23/2021 | Davidson (8-3,7-1) | 49 | at | Butler | 35 | |||
| 10/30/2021 | Butler | 31 | at | Dayton (6-4,5-3) | 38 | |||
| 11/13/2021 | Valparaiso (4-7,4-4) | 47 | at | Butler | 3 | |||
| 11/20/2021 | Butler | 28 | at | Marist (5-5,5-3) | 21 |
| vs Butler | vs Other Opponents | Butler compared to OOs | |
| Record: | 8-3 | 53-53 | |
| Points Scored: | 34.27 | 25.42 | -8.85 |
| Points Allowed: | 23.82 | 27.03 | -3.21 |
| Margin: | 10.45 | -1.61 | -12.06 |
| Total Points: | 58.09 | 52.45 | 5.64 |