| 9/4/2021 | Morehead State | 10 | at | James Madison (12-2) | 68 | at CAAF | ||
| 9/11/2021 | Point (2-9) | 9 | at | Morehead State | 62 | MSC (NAIA) | ||
| 9/18/2021 | Morehead State | 35 | at | Austin Peay (6-5) | 59 | at OVC | ||
| 10/2/2021 | Dayton (6-4,5-3) | 38 | at | Morehead State | 45 | OT | ||
| 10/9/2021 | Morehead State | 38 | at | Presbyterian (2-9,0-8) | 30 | |||
| 10/16/2021 | Butler (3-8,1-7) | 8 | at | Morehead State | 31 | |||
| 10/23/2021 | Morehead State | 27 | at | Marist (5-5,5-3) | 24 | |||
| 10/30/2021 | Davidson (8-3,7-1) | 29 | at | Morehead State | 22 | |||
| 11/6/2021 | Morehead State | 3 | at | San Diego (7-4,7-1) | 10 | |||
| 11/13/2021 | Stetson (3-7,1-6) | 35 | at | Morehead State | 36 | |||
| 11/20/2021 | Morehead State | 51 | at | Valparaiso (4-7,4-4) | 38 |
| vs Morehead State | vs Other Opponents | Morehead State compared to OOs | |
| Record: | 4-7 | 54-56 | |
| Points Scored: | 31.64 | 28.64 | -3.00 |
| Points Allowed: | 32.73 | 30.33 | 2.40 |
| Margin: | -1.09 | -1.69 | -0.60 |
| Total Points: | 64.37 | 58.97 | 5.40 |