| 9/4/2021 | Tarleton State | 10 | at | Stephen F. Austin (8-4,6-2) | 20 | |||
| 9/11/2021 | Fort Lewis (0-11) | 7 | at | Tarleton State | 54 | RMAC (D2) | ||
| 9/18/2021 | Southern Utah (1-10) | 40 | vs | Tarleton State | 35 | Arlington TX | BSky | |
| 9/25/2021 | New Mexico Highlands (4-6) | 21 | at | Tarleton State | 40 | RMAC (D2) | ||
| 10/2/2021 | Tarleton State | 3 | at | Eastern Kentucky (7-4,5-2) | 20 | |||
| 10/16/2021 | Tarleton State | 41 | at | Dixie State (1-10,0-3) | 20 | |||
| 10/23/2021 | Midwestern State (7-3) | 14 | at | Tarleton State | 17 | LSC (D2) | ||
| 10/30/2021 | Sam Houston (11-1,8-0) | 45 | at | Tarleton State | 27 | |||
| 11/6/2021 | Lamar (2-9,0-8) | 21 | at | Tarleton State | 42 | |||
| 11/13/2021 | Tarleton State | 3 | at | Abilene Christian (5-6,3-5) | 29 | |||
| 11/20/2021 | Central Arkansas (5-6,3-4) | 3 | at | Tarleton State | 24 |
| vs Tarleton State | vs Other Opponents | Tarleton State compared to OOs | |
| Record: | 5-6 | 46-64 | |
| Points Scored: | 21.82 | 26.69 | 4.87 |
| Points Allowed: | 26.91 | 31.45 | -4.54 |
| Margin: | -5.09 | -4.76 | 0.33 |
| Total Points: | 48.73 | 58.14 | -9.41 |