| 9/4/2021 | Eastern Kentucky | 31 | at | Western Carolina (4-7) | 28 | at SoCon | ||
| 9/11/2021 | Eastern Kentucky | 3 | at | Louisville (6-7) | 30 | at ACC | ||
| 9/18/2021 | Indiana State (5-6) | 23 | at | Eastern Kentucky | 21 | MVC | ||
| 9/25/2021 | Austin Peay (6-5) | 27 | at | Eastern Kentucky | 35 | OVC | ||
| 10/2/2021 | Tarleton State (6-5,3-4) | 3 | at | Eastern Kentucky | 20 | |||
| 10/9/2021 | Abilene Christian (5-6,3-5) | 15 | at | Eastern Kentucky | 30 | |||
| 10/16/2021 | Eastern Kentucky | 38 | at | Central Arkansas (5-6,3-4) | 35 | |||
| 10/30/2021 | Lamar (2-9,0-8) | 10 | at | Eastern Kentucky | 42 | |||
| 11/6/2021 | Eastern Kentucky | 17 | at | Stephen F. Austin (8-4,6-2) | 31 | |||
| 11/13/2021 | Eastern Kentucky | 28 | at | Sam Houston (11-1,8-0) | 42 | |||
| 11/20/2021 | Jacksonville State (5-6,3-3) | 31 | at | Eastern Kentucky | 39 | 2OT |
| vs Eastern Kentucky | vs Other Opponents | Eastern Kentucky compared to OOs | |
| Record: | 4-7 | 59-55 | |
| Points Scored: | 25.00 | 29.18 | 4.18 |
| Points Allowed: | 27.64 | 27.61 | 0.03 |
| Margin: | -2.64 | 1.57 | 4.21 |
| Total Points: | 52.64 | 56.79 | -4.15 |