| 9/2/2021 | North American U (2-4) | 3 | at | Lamar | 47 | None (Unk?) | ||
| 9/11/2021 | Lamar | 0 | at | Texas-San Antonio (12-2) | 54 | at CUSA | ||
| 9/18/2021 | Lamar | 17 | at | Northern Colorado (3-8) | 10 | OT | at BSky | |
| 9/25/2021 | Abilene Christian (5-6,3-5) | 56 | at | Lamar | 0 | |||
| 10/9/2021 | Lamar | 7 | at | Sam Houston (11-1,8-0) | 41 | |||
| 10/16/2021 | Lamar | 17 | at | Abilene Christian (5-6,3-5) | 24 | |||
| 10/23/2021 | Central Arkansas (5-6,3-4) | 49 | at | Lamar | 38 | |||
| 10/30/2021 | Lamar | 10 | at | Eastern Kentucky (7-4,5-2) | 42 | |||
| 11/6/2021 | Lamar | 21 | at | Tarleton State (6-5,3-4) | 42 | |||
| 11/13/2021 | Jacksonville State (5-6,3-3) | 38 | at | Lamar | 7 | |||
| 11/20/2021 | Stephen F. Austin (8-4,6-2) | 42 | at | Lamar | 6 |
| vs Lamar | vs Other Opponents | Lamar compared to OOs | |
| Record: | 9-2 | 58-50 | |
| Points Scored: | 36.45 | 29.03 | -7.42 |
| Points Allowed: | 15.45 | 28.15 | -12.70 |
| Margin: | 21.00 | 0.88 | -20.12 |
| Total Points: | 51.90 | 57.18 | -5.28 |