| 9/4/2021 | Prairie View (7-5,6-3) | 40 | at | Texas Southern | 17 | |||
| 9/11/2021 | Texas Southern | 7 | at | Baylor (12-2) | 66 | at B12 | ||
| 9/25/2021 | Texas Southern | 34 | at | Rice (4-8) | 48 | at CUSA | ||
| 10/2/2021 | North American U (2-4) | 0 | at | Texas Southern | 69 | None (Unk?) | ||
| 10/9/2021 | Texas Southern | 35 | vs | Southern (4-7,3-5) | 31 | Arlington TX | ||
| 10/16/2021 | Texas Southern | 20 | at | Grambling (4-7,3-5) | 34 | |||
| 10/23/2021 | Alcorn State (6-5,5-3) | 44 | at | Texas Southern | 27 | |||
| 10/30/2021 | Ark Pine Bluff (2-9,1-7) | 17 | at | Texas Southern | 59 | |||
| 11/6/2021 | Texas Southern | 21 | at | Jackson State (11-2,9-0) | 41 | |||
| 11/13/2021 | Alabama A&M (7-3,5-3) | 52 | at | Texas Southern | 49 | |||
| 11/20/2021 | Texas Southern | 21 | at | Alabama State (5-6,3-5) | 24 |
| vs Texas Southern | vs Other Opponents | Texas Southern compared to OOs | |
| Record: | 8-3 | 56-55 | |
| Points Scored: | 36.09 | 24.14 | -11.95 |
| Points Allowed: | 32.64 | 28.70 | 3.94 |
| Margin: | 3.45 | -4.56 | -8.01 |
| Total Points: | 68.73 | 52.84 | 15.89 |