| 9/4/2021 | Gardner-Webb | 25 | at | Georgia Southern (3-9) | 30 | at SBC | ||
| 9/11/2021 | Gardner-Webb | 10 | at | UNC-Charlotte (5-7) | 38 | at CUSA | ||
| 9/18/2021 | Lincoln PA (1-9) | 0 | at | Gardner-Webb | 56 | CIAA (D2) | ||
| 9/25/2021 | Western Carolina (4-7) | 34 | at | Gardner-Webb | 52 | SoCon | ||
| 10/2/2021 | Gardner-Webb | 17 | at | Monmouth NJ (7-4,6-1) | 54 | |||
| 10/9/2021 | Campbell (3-8,2-5) | 42 | at | Gardner-Webb | 28 | |||
| 10/23/2021 | Robert Morris (4-6,3-5) | 17 | at | Gardner-Webb | 28 | |||
| 10/30/2021 | Gardner-Webb | 30 | at | Kennesaw St (11-2,7-0) | 34 | |||
| 11/6/2021 | Gardner-Webb | 21 | at | Hampton (5-6,3-4) | 27 | OT | ||
| 11/13/2021 | Charleston Southern (4-6,3-4) | 32 | at | Gardner-Webb | 24 | 2OT | ||
| 11/20/2021 | Gardner-Webb | 35 | at | North Carolina A&T (5-6,3-4) | 27 |
| vs Gardner-Webb | vs Other Opponents | Gardner-Webb compared to OOs | |
| Record: | 7-4 | 45-66 | |
| Points Scored: | 30.45 | 24.50 | -5.95 |
| Points Allowed: | 29.64 | 30.24 | -0.60 |
| Margin: | 0.81 | -5.74 | -6.55 |
| Total Points: | 60.09 | 54.74 | 5.35 |