| 9/4/2021 | Northwestern State | 14 | at | North Texas (6-7) | 44 | at CUSA | ||
| 9/11/2021 | Northwestern State | 10 | at | Alcorn State (6-5) | 13 | at SWAC | ||
| 9/18/2021 | Tennessee-Martin (10-3) | 35 | at | Northwestern State | 10 | OVC | ||
| 10/2/2021 | Incarnate Word (10-3,7-1) | 38 | at | Northwestern State | 27 | |||
| 10/9/2021 | Northwestern State | 21 | at | Houston Baptist (0-11,0-8) | 17 | |||
| 10/16/2021 | McNeese State (4-7,3-5) | 35 | at | Northwestern State | 17 | |||
| 10/23/2021 | Southeastern Louisiana (9-4,6-2) | 51 | at | Northwestern State | 14 | |||
| 10/30/2021 | Northwestern State | 21 | at | Nicholls State (6-5,5-3) | 42 | |||
| 11/6/2021 | Houston Baptist (0-11,0-8) | 24 | at | Northwestern State | 28 | |||
| 11/13/2021 | Northwestern State | 28 | at | Southeastern Louisiana (9-4,6-2) | 56 | |||
| 11/20/2021 | Northwestern State | 24 | at | McNeese State (4-7,3-5) | 20 |
| vs Northwestern State | vs Other Opponents | Northwestern State compared to OOs | |
| Record: | 8-3 | 53-61 | |
| Points Scored: | 34.09 | 31.86 | -2.23 |
| Points Allowed: | 19.45 | 32.84 | -13.39 |
| Margin: | 14.64 | -0.98 | -15.62 |
| Total Points: | 53.54 | 64.70 | -11.16 |