| 9/2/2021 | Texas A&M-Commerce | 12 | at | Colorado State-Pueblo | 6 | @ RMAC | ||
| Central Washington | 66 | at | Eastern New Mexico | 24 | GNWAC | |||
| Angelo State | 40 | at | Lindenwood | 20 | @ MAIAA | |||
| Texas College | 0 | at | West Texas A&M | 73 | Soon (NAIA) | |||
| 9/4/2021 | Western New Mexico | 35 | at | Adams State | 17 | @ RMAC | ||
| Midwestern State | 48 | at | Quincy | 27 | @ GLV | |||
| Texas A&M-Kingsville | 9 | at | Saginaw Valley State | 13 | @ GLIAC | |||
| Texas-Permian Basin | 24 | at | Southwest Baptist | 16 | @ GLV | |||
| 9/11/2021 | Angelo State | 28 | at | Chadron State | 24 | @ RMAC | ||
| Adams State | 14 | at | Eastern New Mexico | 42 | RMAC | |||
| Midwestern State | 31 | vs | Texas A&M-Commerce | 30 | Arlington TX | |||
| Western Oregon | 10 | at | Texas A&M-Kingsville | 24 | GNWAC | |||
| West Texas A&M | 31 | at | Texas-Permian Basin | 42 | ||||
| Western Colorado | 49 | at | Western New Mexico | 14 | RMAC | |||
| 9/18/2021 | Texas-Permian Basin | 9 | at | Abilene Christian | 34 | @ WAC (1AA) | ||
| Midwestern State | 35 | at | Angelo State | 17 | ||||
| Texas A&M-Kingsville | 36 | at | Eastern New Mexico | 10 | ||||
| West Florida | 35 | at | Texas A&M-Commerce | 17 | GSC | |||
| Western New Mexico | 14 | at | West Texas A&M | 42 | ||||
| 9/25/2021 | Angelo State | 14 | at | Central Washington | 9 | @ GNWAC | ||
| Eastern New Mexico | 24 | at | Midwestern State | 31 | OT | |||
| Texas A&M-Commerce | 35 | at | Texas A&M-Kingsville | 10 | ||||
| Colorado Mines | 21 | at | West Texas A&M | 13 | RMAC | |||
| Texas-Permian Basin | 27 | at | Western New Mexico | 19 | ||||
| 10/2/2021 | Western New Mexico | 3 | at | Angelo State | 62 | |||
| Midwestern State | 20 | at | Central Washington | 30 | @ GNWAC | |||
| Lincoln CA | 6 | at | Eastern New Mexico | 52 | None (Unk?) | |||
| Texas-Permian Basin | at | Simon Fraser | Canceled | @ GNWAC | ||||
| Fort Lauderdale | 6 | at | Texas A&M-Commerce | 72 | None (Unk?) | |||
| West Texas A&M | 38 | at | Western Oregon | 41 | @ GNWAC | |||
| 10/9/2021 | Texas A&M-Kingsville | 13 | at | Midwestern State | 30 | |||
| Saginaw Valley State | 20 | at | Texas A&M-Commerce | 17 | OT | GLIAC | ||
| Lincoln CA | 0 | at | Texas-Permian Basin | 75 | None (Unk?) | |||
| Angelo State | 15 | at | West Texas A&M | 31 | ||||
| Eastern New Mexico | 50 | at | Western New Mexico | 47 | ||||
| 10/16/2021 | Texas-Permian Basin | 14 | at | Angelo State | 34 | |||
| West Texas A&M | 44 | at | Eastern New Mexico | 24 | ||||
| Western New Mexico | 0 | at | Texas A&M-Commerce | 58 | ||||
| Lincoln CA | 21 | at | Texas A&M-Kingsville | 51 | None (Unk?) | |||
| 10/23/2021 | Simon Fraser | 10 | at | Angelo State | 51 | GNWAC | ||
| Midwestern State | 14 | at | Tarleton State | 17 | @ WAC (1AA) | |||
| Eastern New Mexico | 21 | at | Texas-Permian Basin | 44 | ||||
| Texas A&M-Commerce | 15 | at | West Texas A&M | 3 | ||||
| Texas A&M-Kingsville | 28 | at | Western New Mexico | 19 | ||||
| 10/30/2021 | Angelo State | 59 | at | Eastern New Mexico | 7 | |||
| Western New Mexico | 10 | at | Midwestern State | 52 | ||||
| Texas-Permian Basin | 0 | at | Texas A&M-Commerce | 41 | ||||
| West Texas A&M | 35 | at | Texas A&M-Kingsville | 23 | ||||
| 11/6/2021 | Texas A&M-Commerce | 3 | at | Angelo State | 30 | |||
| Eastern New Mexico | 70 | at | North American U | 21 | @ None (Unk?) | |||
| Texas A&M-Kingsville | 29 | at | Texas-Permian Basin | 22 | ||||
| Midwestern State | 12 | at | West Texas A&M | 15 | ||||
| Central Washington | 54 | at | Western New Mexico | 29 | GNWAC | |||
| 11/13/2021 | Texas-Permian Basin | 30 | at | Midwestern State | 36 | |||
| Eastern New Mexico | 10 | at | Texas A&M-Commerce | 30 | ||||
| Angelo State | 58 | at | Texas A&M-Kingsville | 19 | ||||
| Bethel KS | 9 | at | West Texas A&M | 52 | KCAC (NAIA) | |||
| 11/20/2021 | Minnesota-Duluth | 14 | at | Angelo State | 48 | NSIC | ||
| 11/27/2021 | Nebraska-Kearney | 7 | at | Angelo State | 20 | MAIAA | ||
| 12/4/2021 | Angelo State | 26 | at | Colorado Mines | 34 | @ RMAC | ||
| Oklahoma Baptist | 24 | at | Texas-Permian Basin | 21 | GAC |