| 9/2/2021 | Missouri Southern (3-8,2-8) | 0 | at | Nebraska-Kearney | 38 | | | |
| 9/11/2021 | Nebraska-Kearney | 28 | at | Pittsburg State (8-3,7-3) | 17 | | | |
| 9/18/2021 | Washburn (9-3,8-2) | 24 | at | Nebraska-Kearney | 28 | | | |
| 9/25/2021 | Nebraska-Kearney | 31 | at | Central Missouri (4-7,3-7) | 28 | | | |
| 10/2/2021 | Nebraska-Kearney | 35 | at | Fort Hays State (5-6,4-6) | 42 | | | |
| 10/9/2021 | Missouri Western (6-5,5-5) | 14 | at | Nebraska-Kearney | 35 | | | |
| 10/16/2021 | Nebraska-Kearney | 42 | at | Emporia State (6-6,5-5) | 35 | | | |
| 10/23/2021 | Lincoln MO (0-10) | 0 | at | Nebraska-Kearney | 56 | | | GLV |
| 10/30/2021 | Nebraska-Kearney | 13 | at | Northwest Missouri State (11-2,9-1) | 66 | | | |
| 11/6/2021 | Nebraska-Kearney | 37 | at | Central Oklahoma (4-7,3-7) | 22 | | | |
| 11/13/2021 | Northeastern State (2-9,1-9) | 10 | at | Nebraska-Kearney | 56 | | | |
| 11/20/2021 | Nebraska-Kearney | 31 | at | Western Colorado (10-2) | 24 | | | at RMAC |
| 11/27/2021 | Nebraska-Kearney | 7 | at | Angelo State (11-3) | 20 | | | at LSC |