| 8/30/2018 | Indianapolis | 7 | at | Grand Valley State | 30 | @ GLIAC | ||
| Quincy | 0 | at | Indiana State | 49 | @ MVC (1AA) | |||
| Eastern New Mexico | 14 | at | Missouri S&T | 31 | LSC | |||
| Michigan Tech | 20 | at | Truman State | 10 | GLIAC | |||
| 9/1/2018 | William Jewell | at | Drake | CCD | @ Pio (1AA) | |||
| Southwest Baptist | 7 | at | Houston Baptist | 49 | @ SLC (1AA) | |||
| Lincoln MO | 10 | vs | Lane | 7 | Memphis TN | vs SIAC | ||
| Northern Michigan | 28 | at | McKendree | 34 | GLIAC | |||
| 9/6/2018 | Lincoln MO | 24 | at | Missouri State | 52 | @ MVC (1AA) | ||
| 9/8/2018 | Wayne State MI | 6 | at | Indianapolis | 28 | GLIAC | ||
| McKendree | 34 | at | Kentucky State | 17 | @ SIAC | |||
| Southwest Baptist | 9 | at | Mississippi College | 34 | @ GSC | |||
| Missouri S&T | 27 | at | Northwood | 16 | @ GLIAC | |||
| Kentucky Wesleyan | 24 | at | Quincy | 31 | GMAC | |||
| Morningside | 35 | at | Truman State | 17 | GPAC (NAIA) | |||
| Texas A&M-Commerce | 27 | at | William Jewell | 17 | LSC | |||
| 9/15/2018 | Missouri S&T | 12 | at | Drake | 52 | @ Pio (1AA) | ||
| William Jewell | 17 | at | Findlay | 58 | @ GMAC | |||
| Wisconsin-Oshkosh | 17 | at | Lincoln MO | 7 | WIAC (D3) | |||
| Bowie State | 47 | at | McKendree | 41 | CIAA | |||
| St Francis IL | 41 | at | Quincy | 26 | MSFA (NAIA) | |||
| Truman State | 20 | at | Saginaw Valley State | 21 | @ GLIAC | |||
| 9/22/2018 | McKendree | 45 | at | Chowan | 55 | @ CIAA | ||
| William Jewell | 14 | at | Indianapolis | 41 | ||||
| Southwest Baptist | 13 | at | Lincoln MO | 28 | ||||
| Davenport | 26 | at | Quincy | 10 | GLIAC | |||
| Missouri S&T | 16 | at | Tuskegee | 7 | @ SIAC | |||
| Truman State | 34 | at | Valparaiso | 20 | @ Pio (1AA) | |||
| 9/29/2018 | Lincoln MO | 17 | at | Indianapolis | 41 | |||
| McKendree | 48 | at | Quincy | 14 | ||||
| Missouri S&T | 48 | at | Southwest Baptist | 23 | ||||
| William Jewell | 20 | at | Truman State | 27 | ||||
| 10/6/2018 | Quincy | 14 | at | Lincoln MO | 13 | |||
| Truman State | 45 | at | McKendree | 38 | ||||
| Indianapolis | 24 | at | Missouri S&T | 17 | ||||
| Southwest Baptist | 10 | at | William Jewell | 14 | ||||
| 10/13/2018 | William Jewell | 21 | at | Missouri S&T | 59 | |||
| Indianapolis | 35 | at | Quincy | 7 | ||||
| McKendree | 26 | at | Southwest Baptist | 23 | ||||
| Lincoln MO | 13 | at | Truman State | 20 | ||||
| 10/20/2018 | McKendree | 10 | at | Indianapolis | 48 | |||
| Missouri S&T | 20 | at | Quincy | 13 | ||||
| Truman State | 38 | at | Southwest Baptist | 14 | ||||
| Lincoln MO | 23 | at | William Jewell | 14 | ||||
| 10/27/2018 | William Jewell | 31 | at | McKendree | 47 | |||
| Lincoln MO | 7 | at | Missouri S&T | 45 | ||||
| Indianapolis | 48 | at | Southwest Baptist | 14 | ||||
| Quincy | 7 | at | Truman State | 41 | ||||
| 11/3/2018 | Missouri S&T | 49 | at | McKendree | 20 | |||
| Central Washington | 74 | at | Southwest Baptist | 28 | GNWAC | |||
| Lincoln MO | 3 | at | Tarleton State | 59 | @ LSC | |||
| Indianapolis | 31 | at | Truman State | 7 | ||||
| Quincy | 23 | at | William Jewell | 17 | ||||
| 11/10/2018 | Hillsdale | 24 | at | Indianapolis | 34 | GMAC | ||
| McKendree | 50 | at | Lincoln MO | 32 | ||||
| Truman State | 33 | at | Missouri S&T | 34 | ||||
| Southwest Baptist | 21 | at | Quincy | 24 | ||||
| Ferris State | 47 | at | William Jewell | 6 | GLIAC | |||
| 11/17/2018 | Fort Hays State | 27 | at | Indianapolis | 38 | D2 Playoff Round 1 | MAIAA | |
| 11/24/2018 | Indianapolis | 7 | at | Ouachita | 35 | @ GAC | ||
| 12/1/2018 | Minnesota State-Moorhead | 16 | vs | Missouri S&T | 51 | Excelsior Springs MO | vs NSIC |