| 9/1/2018 | Tuskegee | 20 | at | Alabama State (4-7) | 26 | OT | at SWAC | |
| 9/8/2018 | Albany State GA (7-4,6-2) | 0 | vs | Tuskegee | 20 | Phenix City | ||
| 9/15/2018 | Tuskegee | 24 | at | Clark Atlanta (3-7,2-5) | 17 | |||
| 9/22/2018 | Missouri S&T (10-2) | 16 | at | Tuskegee | 7 | GLV | ||
| 9/29/2018 | Lane (3-6,2-4) | 8 | at | Tuskegee | 17 | |||
| 10/6/2018 | Morehouse (7-3,6-3) | 30 | vs | Tuskegee | 24 | 3OT | Columbus GA | |
| 10/13/2018 | Tuskegee | 17 | at | Fort Valley State (2-8,2-4) | 6 | |||
| 10/20/2018 | Kentucky State (0-10,0-6) | 0 | at | Tuskegee | 37 | |||
| 10/27/2018 | Tuskegee | 36 | at | Central State (5-5,4-3) | 40 | |||
| 11/3/2018 | Tuskegee | 27 | at | Miles (5-6,5-4) | 31 |
| vs Tuskegee | vs Other Opponents | Tuskegee compared to OOs | |
| Record: | 5-5 | 41-53 | |
| Points Scored: | 17.40 | 22.64 | 5.24 |
| Points Allowed: | 22.90 | 27.07 | -4.17 |
| Margin: | -5.50 | -4.43 | 1.07 |
| Total Points: | 40.30 | 49.71 | -9.41 |