| 9/1/2018 | Mercyhurst (5-6) | 9 | at | Hillsdale | 14 | PSAC | ||
| 9/8/2018 | Hillsdale | 30 | at | Michigan Tech (4-6) | 31 | OT | at GLIAC | |
| 9/15/2018 | Hillsdale | 34 | at | Ohio Dominican (9-2,6-1) | 18 | |||
| 9/22/2018 | Lake Erie (0-11,0-7) | 7 | at | Hillsdale | 41 | |||
| 9/29/2018 | Hillsdale | 45 | at | Malone (2-8,1-6) | 35 | |||
| 10/6/2018 | Hillsdale | 20 | at | Findlay (8-3,5-2) | 17 | |||
| 10/13/2018 | Alderson-Broaddus (4-7,3-4) | 24 | at | Hillsdale | 45 | |||
| 10/20/2018 | Hillsdale | 28 | at | Walsh (4-6,4-3) | 9 | |||
| 10/27/2018 | Kentucky Wesleyan (3-7,2-5) | 0 | at | Hillsdale | 34 | |||
| 11/3/2018 | Tiffin (9-2) | 26 | at | Hillsdale | 48 | GLIAC | ||
| 11/10/2018 | Hillsdale | 24 | at | Indianapolis (10-2) | 34 | at GLV | ||
| 11/17/2018 | Hillsdale | 40 | at | Kutztown (9-2) | 26 | D2 Playoff Round 1 | at PSAC | |
| 11/24/2018 | Hillsdale | 14 | at | Notre Dame OH (13-1) | 19 | at MtnE |
| vs Hillsdale | vs Other Opponents | Hillsdale compared to OOs | |
| Record: | 3-10 | 77-53 | |
| Points Scored: | 19.62 | 29.74 | 10.12 |
| Points Allowed: | 32.08 | 27.53 | 4.55 |
| Margin: | -12.46 | 2.21 | 14.67 |
| Total Points: | 51.70 | 57.27 | -5.57 |