| 8/30/2018 | Texas A&M-Kingsville (4-7,2-6) | 36 | at | Texas A&M-Commerce | 37 | 2OT | | |
| 9/8/2018 | Texas A&M-Commerce | 27 | at | William Jewell (1-9) | 17 | | | at GLV |
| 9/15/2018 | Texas A&M-Commerce | 21 | at | Eastern New Mexico (5-6,4-4) | 11 | | | |
| 9/22/2018 | Colorado State-Pueblo (11-2) | 23 | at | Texas A&M-Commerce | 13 | | | RMAC |
| 9/29/2018 | Lock Haven (2-9) | 6 | at | Texas A&M-Commerce | 68 | | | PSAC |
| 10/6/2018 | Texas A&M-Commerce | | at | Midwestern State (8-2,6-2) | | | CCD | |
| 10/7/2018 | Texas A&M-Commerce | 20 | vs | Midwestern State (8-2,6-2) | 19 | | Wichita Falls TX/Denton TX | |
| 10/13/2018 | Tarleton State (12-1,9-0) | 47 | at | Texas A&M-Commerce | 21 | | | |
| 10/20/2018 | Texas A&M-Commerce | 55 | at | Western New Mexico (0-10,0-8) | 7 | | | |
| 10/27/2018 | West Texas A&M (6-5,4-4) | 16 | at | Texas A&M-Commerce | 41 | | | |
| 11/3/2018 | Texas A&M-Commerce | 20 | at | Texas-Permian Basin (2-9,1-7) | 17 | | | |
| 11/10/2018 | Angelo State (6-6,4-4) | 13 | at | Texas A&M-Commerce | 41 | | | |
| 11/17/2018 | Texas A&M-Commerce | 33 | at | Minnesota-Duluth (11-1) | 17 | | D2 Playoff Round 1 | at NSIC |
| 11/24/2018 | Texas A&M-Commerce | 28 | at | Tarleton State (12-1,9-0) | 34 | | | |